Provera and Depo-Provera (Medroxyprogesterone Acetate) are made by Pharmacia and Upjohn for the treatment of endometriosis.
What is Provera/Depo-Provera?
Provera/Depo-Provera is a synthetic (artificial) progestogen and is similar to the progesterone produced naturally by the ovaries.
How Provera/Depo-Provera works
Provera/Depo-Provera works by stopping the ovaries ovulating (producing eggs) and tricking the body into a pseudo (false) pregnancy. Periods usually stop during treatment, but return within two to three months of treatment ending.
Administration and dosage of Provera/Depo-Provera
Provera comes in tablet form in strengths of 2.5mgs, 5mgs and 1 0mgs.
Depo-Provera is given as an intra-muscular injection in the buttock or the upper arm.
Provera is started on day one of the monthly cycle (first day of bleeding), 1 0mgs daily for ninety days continuously.
Depo-Provera is given at twelve week intervals. It is important that the injection be given only during the first five days after the beginning of a period.
Some blood spotting may occur during treatment, but no action is required for this.
Provera/Depo-Provera is not suitable for the treatment of children or the elderly.
When Provera/Depo-Provera should not be used (contra-indications)
- Liver disease
- Lactating women (breast feeding)
- Undiagnosed vaginal bleeding
- History of thrombosis
- Undiagnosed urinary tract bleeding
- Oestrogen dependent cancer
- Patients with a known sensitivity to Provera/Depo-Provera
Precautions in the use of Provera/Depo-Provera
- Diabetic patients should be regularly checked. Epileptic patients should be regularly checked.
- Patients with high blood pressure should have regular blood pressure checks.
- Patients receiving treatment for depression should be monitored closely.
- Patients with asthma need regular peak flow checks. Patients with kidney problems require close monitoring.
Side effects of Provera/Depo-Provera
- Weight gain
- Irregular bleeding
- Bloating/fluid retention
- Sore breasts
- Loss of sleep
- Increased hair growth
- Skin rash
- Hair loss
- Dry sore vagina
As with all treatments, you may have no side effects at all, or you may have a few but it is rare to experience multiple side effects.
Do remember to report any side effects to your medical practitioner and ask for advice.
Notes on Provera/Depo-Provera
Make sure that you are not pregnant before starting treatment. A pregnancy test is advisable.